The Institute of Molecular Medicine (IMM) celebrates its 10th anniversary. It has over 660 employees, and now it has 500 researchers, of whom 206 have PhDs and 30 are foreigners. The IMM has 38 research units and three start-ups (technology-based companies at development stage), encompassing research groups in the fields of rheumatic diseases, neurosciences, vascular diseases, movement, dementia, immuno-allergology, and cancer. The research carried out at the IMM is clinically oriented to diseases of the 21st century, such as cancer, Alzheimer’s disease, cardiovascular diseases (stroke), rheumatic diseases (rheumatoid arthritis), infectious diseases (HIV/AIDS), and malaria, among others. Currently the IMM has 89 PhD students, of whom 30% are physicians. The large majority of IMM graduates are employees of the university (82%), work in hospitals (5%) or in the industry (4%). Over the last ten years there have been numerous advances in Portuguese science and medicine as a result of research conducted at the IMM. Of these, the ten most significant discoveries since the creation of the institution are listed below:
1. Genetic mutations that trigger leukaemia;
2. A new strategy to inhibit the replication of the dengue virus;
3. HDAC9 gene at risk of causing stroke;
4. New treatment for sepsis;
5. Infection by the malaria parasite prevents new infection;
6. Getting closer to malaria vaccine;
7. Differentiating T cells to fight cancer more effectively;
8. Immune hyperactivation determines progression of AIDS;
9. Essential cells in the control and development of the gut;
10. Treatment for rheumatoid arthritis and agreement with China.
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