The effects of glucose in the treatment of cancer with immune cells


A study  conducted by the research team led by Professor Bruno Silva Santos, from iMM JLA, which reveals that glucose added to gamma-delta T lymphocytes (immune cells), prepared in the laboratory to be used as cancer therapy, makes them “have much increased anti-tumour capacity, inhibiting tumour growth”.

“This is not a 'diet' rich in sugar! This type of food would also help the tumour to grow, so it is not recommended”, the Professor told Lusa.

The same study also revealed that, “high cholesterol concentrations favour pro-tumour immune functions, the production of molecules that help the tumour to grow”.

Bruno Silva Santos' team studied the metabolism of gamma-delta T lymphocytes grown in the laboratory and monitored “their impact on the multiplication and production of essential molecules for the response to tumours”, having subsequently injected these cells into mice with breast cancer and colorectal cancer, following the development or growth of the tumour.

T lymphocytes are generated in the thymus, a gland located above the heart, including gamma-delta T lymphocytes. They receive instructions on "the correspondence between glucose and anti-tumour functions and between cholesterol and pro-tumour functions".


Additional information here.